Diuretic effects of L-threo-3,4-dihydroxyphenylserine(L-threo-DOPS) in anesthetized rats.
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منابع مشابه
Inhibitory effect of (+)threo-3,4-dihydroxy-phenylserine (DOPS) on decarboxylation of (-)threo-dops.
The decarboxylation of racemic threo and erythro-3,4-dihydroxyphenylserine (DOPS), norepinephrine (NE) precursors, has been reported in mammalian peripheral and central nervous system tissues in vivo (1-5). It has also been demonstrated both in vitro and in vivo that the rate of racemic erythro-DOPS decarboxylation is more rapid than that of racemic threo-DOPS (6). A recent report on the action...
متن کاملInhibitory effects of L-threo-DOPS, an L-noradrenaline precursor, on locus coeruleus-originating neurons in the caudate nucleus.
Electrophysiological studies using reserpine-treated cats were carried out to elucidate the effects of L-threo-3,4-dihydroxyphenylserine (L-threo-DOPS) on the noradrenergic pathway from the locus coeruleus (LC) to the caudate nucleus (CN) neurons, which were activated by iontophoretically applied bromocriptine, a dopamine D-2 receptor agonist. In the CN neurons, glutamate-induced firing was inh...
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A novel type of NADPH-dependent sepiapterin reductase, which catalysed uniquely the reduction of sepiapterin to l-threo-dihydrobiopterin, was purified 533-fold from the cytosolic fraction of Chlorobium tepidum, with an overall yield of 3%. The native enzyme had a molecular mass of 55 kDa and SDS/PAGE revealed that the enzyme consists of two subunits with a molecular mass of 26 kDa. The enzyme w...
متن کاملThe effects of D- and L-threo-chloramphenicol on the early development of the chick embryo.
I N many bacterial systems chloramphenicol has been shown to inhibit protein synthesis (Hahn & Wisseman, 1951; Gale & Folkes, 1953). The precise mechanism of this inhibition is not clear, although the evidence suggests that the interaction of the soluble RNA-amino acid complex with the ribosomes is prevented because the attachment of the messenger RNA to the ribosomes is itself impaired (Lacks ...
متن کاملCharacterization of Novel L-threo- -Benzyloxyaspartate Derivatives, Potent Blockers of the Glutamate Transporters
Nontransportable blockers of the glutamate transporters are important tools for investigating mechanisms of synaptic transmission. DL-threo-Benzyloxyaspartate (DL-TBOA) is a potent blocker of all subtypes of the excitatory amino acid transporters (EAATs). We characterized novel L-TBOA analogs possessing a substituent on their respective benzene rings. The analogs significantly inhibited labeled...
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ژورنال
عنوان ژورنال: The Japanese Journal of Pharmacology
سال: 1990
ISSN: 0021-5198,1347-3506
DOI: 10.1254/jjp.52.431